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Lieske et al., 2020)

doi: 10.1136/bmj.l4673 216

DNA sample showed the presence of deoxyguanosine adducts of 4-hydroxyestradiol and 4-hydroxyestrone in almost every samples [21]

At the molecular level, they modulate inflammation-related gene expression by altering membrane phospholipid composition, disrupting lipid raft integrity, inhibiting nuclear factor kappa B (NF-B), and activating PPAR- , thereby promoting anti-inflammatory mediators and suppressing inflammation (18)